indometacin drug pathway indometacin pharmacodynamics pathway 2015-12-02T14:35:36Z PW:0002305 SMP:00104 The pathway of indometacin-target interaction and of the biochemical or physiological responses to drug. Indometcin is an inhibitor of cyclooxygenase enzymes used in the treatment of pain and inflammation and to reduce fever. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri