musculo-skeletal system drug pathway indometacin drug pathway 2015-12-04T08:50:23Z PW:0002313 The pharmacokinetics and pharmacodynamics pathway of indometacin, a non-steroidal anti-inflammatory drug that inhibits cyclooxygenase enzymes. It is commonly used to reduce fever, pain and swelling in wide range of conditions. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. indomethacin drug pathway pathway vpetri