trichlormethiazide drug pathway trichlormethiazide pharmacodynamics pathway 2015-12-07T08:59:19Z PW:0002322 SMP:00121 The pathway of trichlormethiazide-target interaction and of the biochemical or physiological responses to drug. The drug is thought to block reabsorption of chloride and possibly sodium in the ascending loop of Henle. Genetic variations can cause differences in the response of the organism to the drug. pathway vpetri