antiarrhythmic drug pathway mexiletine drug pathway 2015-12-08T14:55:08Z PW:0002337 The pharmacokinetics and pharmacodynamics pathway of mexiletine, a drug used in the treatment of cardiac arrhythmias. Mexiletine is a non-selective voltage-gated sodium channel blocker of the Class IB antiarrhythimc drugs. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri