tioguanine drug pathway tioguanine pharmacodynamics pathway 2015-12-29T13:00:41Z PW:0002394 SMP:00430 The pathway of teniposide-target interactions and of the biochemical or physiological responses to drug. The drug is used in the treatment of several leukemia types, ulcerative colitis and some autoimmune diseases. Derivatives of tioguanine exert several cytotoxic effects. Genetic variations can cause differences in the response of the organism to the drug. pathway thioguanine pharmacodynamics pathway vpetri