anesthetic drug pathway cocaine drug pathway 2016-02-24T10:09:11Z PW:0002533 The pharmacokinetics and pharmacodynamics pathway of cocaine, a drug of few medical uses, mostly as a local anesthetic during surgery. Cocaine is highly addictive due to its effects on the reward system in the brain. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug. pathway vpetri