metabolic disease pathway acid-base imbalance pathway 2016-02-26T09:11:42Z A disturbance that leads to changes in the body's normal balance of acids and bases resulting in deviation from the normal pH range. The imbalance is due to changes in renal or ventilation function. The changes can lead to an excess of acid, acidosis or acidaemia, or to an excess of vases, alkalosis or alkalemia. PW:0002545 pathway vpetri