signaling pathway protease mediated signaling pathway 2016-07-01T10:00:11Z PW:0002606 Proteases, the vitamin K-dependent coagulation proteases in particular, can activate a specific class of G protein-coupled receptors harboring an internally tethered ligand. The four protease-activated receptors (PARs) are involved in numerous physiologically relevant processes and can also play a role in disease-related aspects. PARs can be cleaved at different sites by different proteases to elicit distinct signaling responses, referred to as biased signaling. pathway vpetri