coagulation cascade pathway altered hemostasis pathway altered coagulation cascade pathway 2016-07-14T15:40:03Z Alterations in the coagulation cascade have been associated with several conditions. Deficiencies in factors F5 and F8, the essential cofactors of the intrinsic tenase and thrombinase complexes, lead to parahemophilia and hemophilia A, respectively. PW:0002613 pathway vpetri