cellular detoxification pathway endogenous antioxidant pathway 2016-09-08T08:38:56Z PW:0002622 Several endogenous small proteins are involved in the antioxidant response. Subsequently they need to be reduced back for another round of response, The reductase enzymes catalyze the reaction in an NADPH-dependent manner. The expression of these and of NADPH-producing enzymes is under the control of nuclear factor, erythroid 2 like 2 signaling pathway. pathway vpetri