biogenic amine biosynthetic pathway agmatine biosynthetic pathway 2024-06-05T13:52:45Z Agmatine biosynthesis PW:0002677 Those metabolic reactions involved in the synthesis of agmatine, which is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and hydrolyzed by agmatinase to putrescine. Agmatine binds to several target receptors in the brain and has been proposed as a novel neuromodulator. It has the potential to serve in the coordination of the early and repair phase pathways of arginine in inflammation. agmatine biosynthetic process gthayman pathway