chromatin modification/remodeling pathway epigenetic regulation of gene expression pathway 2025-03-24T13:57:16Z Epigenetic regulation of gene expression PW:0002701 Those metabolic reactions involved in modulating the frequency, rate or extent of gene expression through chromatin remodeling either by modifying higher order chromatin fiber structure or nucleosomal histones, cytosine methylation of DNA or RNA interference. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal. gthayman pathway