nucleotide excision repair pathway transcription-coupled nucleotide-excision repair pathway 2025-04-15T10:47:53Z PW:0002710 The nucleotide-excision repair pathway that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. Pathway impairment is the underlying cause of a severe hereditary disorder, Cockayne syndrome, an autosomal recessive disease characterized by hypersensitivity to UV light. Transcription-Coupled Nucleotide Excision Repair (TC-NER) gthayman pathway transcription-coupled nucleotide-excision repair