part_of M phase pathway mitotic prometaphase pathway 2025-05-07T14:47:31Z Mitotic Prometaphase PW:0002729 The series of events underlying mitotic prometaphase in higher eukaryotes, which follows mitotic prophase, during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles. gthayman pathway