has specified product has specified reactant has_catalyst alkene carboxylic ester titanium atom organomagnesium halide cyclopropanes ring formation reaction step Kulinkovich reaction 2021-12-15T09:10:05Z RXNO RXNO:0000682 The dialkyldialkoxytitanium reagent, which actually reacts with the carboxylic ester, is generated in situ from the Grignard reagent and the titanium(IV) alkoxide. The formation of a substituted cyclopropanol by reaction of a carboxylic ester with a Grignard reagent (carrying a hydrogen atom in the beta-position) in the presence of a titanium(IV) alkoxide as catalyst. A modified cyclopropanol product can be generated by addition of a terminal alkene as a further reactant.