has specified product has specified reactant has_catalyst titanium atom carboxamide organomagnesium halide cyclopropanes ring formation reaction step Kulinkovich-de Meijere reaction 2021-12-15T10:14:52Z RXNO RXNO:0000683 The Kulinkovich-de Meijere reaction is a modification of the Kulinkovich reaction (i.e., the reaction of an amide instead of a carboxylic ester under Kulinkovich conditions). The formation of a substituted cyclopropylamine by reaction of an amide with a Grignard reagent (carrying a hydrogen atom in the beta-position) in the presence of a titanium(IV) alkoxide as catalyst.