enzymatic rate law for irreversible non-modulated non-interacting reactant enzymes enzymatic rate law for irreversible non-modulated non-interacting trireactant enzymes Kinetics of enzymes that react with three substances, their substrates, that bind independently. The enzymes do not catalyse the reactions in both directions. <n0:math xmlns:n0="http://www.w3.org/1998/Math/MathML"> <n2:semantics xmlns:n2="http://biomodels.net/SBO/" definitionURL="http://biomodels.net/SBO/#SBO:0000062"> <n2:lambda> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000505">Et</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kp</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000515">S1</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000515">S2</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000515">S3</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">K1</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">K2</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">K3</n2:ci></n2:bvar> <n2:apply> <n2:divide /> <n2:apply> <n2:times /> <n2:ci>Et</n2:ci> <n2:ci>kp</n2:ci> <n2:apply> <n2:times /> <n2:apply> <n2:divide /> <n2:ci> S1 </n2:ci> <n2:ci> K1 </n2:ci> </n2:apply> <n2:apply> <n2:divide /> <n2:ci> S2 </n2:ci> <n2:ci> K2 </n2:ci> </n2:apply> <n2:apply> <n2:divide /> <n2:ci> S3 </n2:ci> <n2:ci> K3 </n2:ci> </n2:apply> </n2:apply> </n2:apply> <n2:apply> <n2:times /> <n2:apply> <n2:plus /> <n2:cn type="integer">1</n2:cn> <n2:apply> <n2:divide /> <n2:ci> S1 </n2:ci> <n2:ci> K1 </n2:ci> </n2:apply> </n2:apply> <n2:apply> <n2:plus /> <n2:cn type="integer">1</n2:cn> <n2:apply> <n2:divide /> <n2:ci> S2 </n2:ci> <n2:ci> K2 </n2:ci> </n2:apply> </n2:apply> <n2:apply> <n2:plus /> <n2:cn type="integer">1</n2:cn> <n2:apply> <n2:divide /> <n2:ci> S3 </n2:ci> <n2:ci> K3 </n2:ci> </n2:apply> </n2:apply> </n2:apply> </n2:apply> </n2:lambda> </n2:semantics> </n0:math>