enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by non-exclusive non-cooperative inhibitors enzymatic rate law for simple competitive inhibition of irreversible unireactant enzymes by two non-exclusive, non-cooperative inhibitors <n0:math xmlns:n0="http://www.w3.org/1998/Math/MathML"> <n2:semantics xmlns:n2="http://biomodels.net/SBO/" definitionURL="http://biomodels.net/SBO/#SBO:0000062"> <n2:lambda> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000505">Et</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000515">S</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000521">I1</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000521">I2</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki1</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki2</n2:ci></n2:bvar> <n2:apply> <n2:divide /> <n2:apply> <n2:times /> <n2:ci>kcat</n2:ci> <n2:ci>Et</n2:ci> <n2:ci>S</n2:ci> </n2:apply> <n2:apply> <n2:plus /> <n2:apply> <n2:times /> <n2:ci>Ks</n2:ci> <n2:apply> <n2:plus /> <n2:cn type="integer">1</n2:cn> <n2:apply> <n2:divide /> <n2:ci>I1</n2:ci> <n2:ci>Ki1</n2:ci> </n2:apply> <n2:apply> <n2:divide /> <n2:ci>I2</n2:ci> <n2:ci>Ki2</n2:ci> </n2:apply> <n2:apply> <n2:divide /> <n2:apply> <n2:times /> <n2:ci>I1</n2:ci> <n2:ci>I2</n2:ci> </n2:apply> <n2:apply> <n2:times /> <n2:ci>Ki1</n2:ci> <n2:ci>Ki2</n2:ci> </n2:apply> </n2:apply> </n2:apply> </n2:apply> <n2:ci>S</n2:ci> </n2:apply> </n2:apply> </n2:lambda> </n2:semantics> </n0:math> Inhibition of a unireactant enzyme by two inhibitors that can bind independently once to the free enzyme and preclude the binding of the substrate. The enzymes do not catalyse the reactions in both directions. enzymatic rate law for simple competitive inhibition of irreversible unireactant enzymes by two non-exclusive inhibitors