enzymatic rate law for simple competitive inhibition of irreversible unireactant enzymes by two non-exclusive inhibitors Inhibition of a unireactant enzyme by two inhibitors that can bind once to the free enzyme and preclude the binding of the substrate. Binding of one inhibitor may affect binding of the other, or not. The enzymes do not catalyse the reactions in both directions. <n0:math xmlns:n0="http://www.w3.org/1998/Math/MathML"> <n2:semantics xmlns:n2="http://biomodels.net/SBO/" definitionURL="http://biomodels.net/SBO/#SBO:0000062"> <n2:lambda> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000505">Et</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000515">S</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000521">I1</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000521">I2</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000383">a</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki1</n2:ci></n2:bvar> <n2:bvar><n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki2</n2:ci></n2:bvar> <n2:apply> <n2:divide /> <n2:apply> <n2:times /> <n2:ci>kcat</n2:ci> <n2:ci>Et</n2:ci> <n2:ci>S</n2:ci> </n2:apply> <n2:apply> <n2:plus /> <n2:apply> <n2:times /> <n2:ci>Ks</n2:ci> <n2:apply> <n2:plus /> <n2:cn type="integer">1</n2:cn> <n2:apply> <n2:divide /> <n2:ci>I1</n2:ci> <n2:ci>Ki1</n2:ci> </n2:apply> <n2:apply> <n2:divide /> <n2:ci>I2</n2:ci> <n2:ci>Ki2</n2:ci> </n2:apply> <n2:apply> <n2:divide /> <n2:apply> <n2:times /> <n2:ci>I1</n2:ci> <n2:ci>I2</n2:ci> </n2:apply> <n2:apply> <n2:times /> <n2:ci>a</n2:ci> <n2:ci>Ki1</n2:ci> <n2:ci>Ki2</n2:ci> </n2:apply> </n2:apply> </n2:apply> </n2:apply> <n2:ci>S</n2:ci> </n2:apply> </n2:apply> </n2:lambda> </n2:semantics> </n0:math> enzymatic rate law for modulated unireactant enzymes