enzymatic rate law for multireactant enzymes Ordered Bi-Bi mechanism rate law Enzymatic rate law for a reaction involving two substrates and two products. The products P and then Q are released strictly in order, while the substrates are bound strictly in the order A and then B. <n0:math xmlns:n0="http://www.w3.org/1998/Math/MathML"> <n2:semantics xmlns:n2="http://biomodels.net/SBO/" definitionURL="http://biomodels.net/SBO/#SBO:0000062"> <n2:lambda> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000515">Sa</n2:ci> </n2:bvar> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000515">Sb</n2:ci> </n2:bvar> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000512">Pp</n2:ci> </n2:bvar> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000512">Pq</n2:ci> </n2:bvar> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000281"> Keq </n2:ci> </n2:bvar> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000324"> Vf </n2:ci> </n2:bvar> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000325"> Vr </n2:ci> </n2:bvar> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000322"> Kma </n2:ci> </n2:bvar> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000322"> Kmb </n2:ci> </n2:bvar> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000323"> Kmp </n2:ci> </n2:bvar> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000323"> Kmq </n2:ci> </n2:bvar> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000261"> Kia </n2:ci> </n2:bvar> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000261"> Kib </n2:ci> </n2:bvar> <n2:bvar> <n2:ci definitionURL="http://biomodels.net/SBO/#SBO:0000261"> Kip </n2:ci> </n2:bvar> <n2:apply> <n2:divide /> <n2:apply> <n2:times /> <n2:ci> Vf </n2:ci> <n2:apply> <n2:minus /> <n2:apply> <n2:times /> <n2:ci>Sa</n2:ci> <n2:ci>Sb</n2:ci> </n2:apply> <n2:apply> <n2:divide /> <n2:apply> <n2:times /> <n2:ci>Pp</n2:ci> <n2:ci>Pq</n2:ci> </n2:apply> <n2:ci> Keq </n2:ci> </n2:apply> </n2:apply> </n2:apply> <n2:apply> <n2:plus /> <n2:apply> <n2:times /> <n2:ci>Sa</n2:ci> <n2:ci>Sb</n2:ci> <n2:apply> <n2:plus /> <n2:cn> 1 </n2:cn> <n2:apply> <n2:divide /> <n2:ci>Pp</n2:ci> <n2:ci> Kip </n2:ci> </n2:apply> </n2:apply> </n2:apply> <n2:apply> <n2:times /> <n2:ci> Kma </n2:ci> <n2:ci>Sb</n2:ci> </n2:apply> <n2:apply> <n2:times /> <n2:ci> Kmb </n2:ci> <n2:apply> <n2:plus /> <n2:ci>Sa</n2:ci> <n2:ci> Kia </n2:ci> </n2:apply> </n2:apply> <n2:apply> <n2:times /> <n2:apply> <n2:divide /> <n2:ci> Vf </n2:ci> <n2:apply> <n2:times /> <n2:ci> Vr </n2:ci> <n2:ci> Keq </n2:ci> </n2:apply> </n2:apply> <n2:apply> <n2:plus /> <n2:apply> <n2:times /> <n2:ci> Kmq </n2:ci> <n2:ci>Pp</n2:ci> <n2:apply> <n2:plus /> <n2:cn> 1 </n2:cn> <n2:apply> <n2:divide /> <n2:ci>Sa</n2:ci> <n2:ci> Kia </n2:ci> </n2:apply> </n2:apply> </n2:apply> <n2:apply> <n2:times /> <n2:ci>Pq</n2:ci> <n2:apply> <n2:plus /> <n2:apply> <n2:times /> <n2:ci> Kmp </n2:ci> <n2:apply> <n2:plus /> <n2:cn> 1 </n2:cn> <n2:apply> <n2:divide /> <n2:apply> <n2:times /> <n2:ci> Kma </n2:ci> <n2:ci>Sb</n2:ci> </n2:apply> <n2:apply> <n2:times /> <n2:ci> Kia </n2:ci> <n2:ci> Kmb </n2:ci> </n2:apply> </n2:apply> </n2:apply> </n2:apply> <n2:apply> <n2:times /> <n2:ci>Pp</n2:ci> <n2:apply> <n2:plus /> <n2:cn> 1 </n2:cn> <n2:apply> <n2:divide /> <n2:ci>Sb</n2:ci> <n2:ci> Kib </n2:ci> </n2:apply> </n2:apply> </n2:apply> </n2:apply> </n2:apply> </n2:apply> </n2:apply> </n2:apply> </n2:apply> </n2:lambda> </n2:semantics> </n0:math>