hybrid non-spatial framework hybrid flux balance-logical-deterministic continuous non-spatial framework Modeling approach which combines flux-balance [SBO:0000624], non-spatial deterministic continuous [SBO:0000675], and logical [SBO:0000234] simulation. For example, a metabolic network could be simulated using flux balance analysis, while the expression metabolic enzymes could be co-simulated with a logical simulation method and a signaling network could be co-simulated with a method for integrating ordinary differential equations such as CVODE.