in guideline Opioid Methadone A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of morphine. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. http://www.drugbank.ca/drugs/DB00333 Physeptone SCDO:0000752 Sufficient CHEBI:6807 6-(dimethylamino)-4,4-diphenylheptan-3-one Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit Evidence-Based Management of Sickle Cell Disease