treated with diagnosed by in guideline Glomerulonephritis Variety of causes - in sickle cell disease, most common lesion is focal segmental glomerulosclerosis (FSGS) but also reported Membranoproliferative glomerulonephritis and other forms of glomerulonephritis. Inflammation of the renal glomeruli. HP:0000099 Sufficient SCDO:0000458 Provide source for additional info. May occur at any age. Patients with hematuria may have dark-colored urine. Glomerulonephritis may lead to the proteinuria and "foamy" appearance of the urine. If the latter is substantial, patients may develop clinically evident edema. Glomerular Nephritis GN Nephritis Hematuria Proteinuria Treatment of Precipitating Factors Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada Evidence-Based Management of Sickle Cell Disease