treated with in guideline Acne Break Out HP:0001061 SCDO:0000012 Sufficient A skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts). Breaking Out Skin Inflammation Antibiotic Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit