modifies Mutation A permanent change in the DNA sequence of a gene that alters the genetic message carried by that gene. IDOMAL:50000026 Sufficient SCDO:0001370 Perhaps include here an "Alpha Thalassemia Mutation" sub-class? Could use the current description for "Alpha-Globin Locus Deletion" and instead give "Alpha-Globin Locus Deletion" a description similar to that of "Beta-Globin Locus Deletion" http://purl.obolibrary.org/obo/IDOMAL_50000026 Gene Product Genetic Variation