caused by in guideline Abnormality of the Immune System Sickle Cell Dactylitis NCIT:C28516 http://purl.obolibrary.org/obo/NCIT_C28516 Sufficient A severe acute inflammatory response affecting the hands and feet of individuals with sickle cell disease, sickle cell-hemoglobin C disease or sickle cell-beta-thalassemia. It is caused by vaso-occlusive episodes leading to ischemia and finally infarction of the distal portions of the extremities. Clinical signs of pain, swelling and tenderness of digits usually begin in early childhood and may be the initial manifestations of sickle cell anemia. Clinical course is self-limited with instances typically lasting a few weeks and occurring during sickling crises. An initial episode before the age of 1 strongly correlates with a more severe disease course. SCDO:0000477 SCD Related Pain Vaso-Occlusion Recommendations for the Management of Sickle Cell Disease in South Africa National Guideline for the Control and Management of Sickle Cell Disease Management of Sickle Cell Disease - The United Republic of Tanzania A Parental Guide to Managing Sickle Cell Disease Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care Evidence-Based Management of Sickle Cell Disease Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children