treats in guideline Non-Steroidal Anti-Inflammatory Drug Antipyretic Cervical Cord Compression Ibuprofen Advil A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Sufficient NCIT:C561 Ibuprophen http://www.drugbank.ca/drugs/DB01050 Motrin SCDO:0000606 2-[4-(2-methylpropyl)phenyl]propanoic acid Sickle Cell Disease-S Beta Minus Thalassemia Management of Sickle Cell Disease - The United Republic of Tanzania A Parental Guide to Managing Sickle Cell Disease Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children