treats in guideline Drug Amitriptyline Sufficient Used to treat neuropathic pain http://purl.obolibrary.org/obo/NCIT_C62005 A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity. NCIT:C62005 SCDO:0004190 Chronic Neuropathic Pain Symptomatic Therapeutics Management of Sickle Cell Disease - The United Republic of Tanzania Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit