treats in guideline Pregabalin PD 144723 3-Isobutyl GABA NCIT:C64625 CI 1008 Lyrica http://purl.obolibrary.org/obo/NCIT_C64625 3-(Aminomethyl)-5-methyl-hexanoic Acid Sufficient SCDO:0008454 A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation. Chronic Neuropathic Pain Non Opioid ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children