APOL1 APO-L Apolipoprotein L1 Gene Exists in other ontologies but we have provided a description more relevant to its relationship with SCD. Not relevant to context of sickle cell APOL1 Gene http://www.ncbi.nlm.nih.gov/gene/8542 APOL This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Variants in the APOL1 gene can influence susceptibility to end-stage renal disease and Trypanosomiasis (African Sleeping Sickness). Non-Globin Gene