in guideline Breakthrough Pain Evidence-Based Management of Sickle Cell Disease: Expert Panel Report (EPR), 2014 There are currently no data that clearly describe or can be used to define breakthrough pain in SCD. An episode of severe pain that occurs with rapid onset even when pain-control medication is being used. Breakthrough pain can occur spontaneously or in relation to a specific activity, and can last from a few seconds to a few hours. NCIT:C9203 Evidence-Based Management of Sickle Cell Disease: Expert Panel Report (EPR), 2014 Few but definitions not specific enough Chronic Sickle Cell Pain Recommendations for the Management of Sickle Cell Disease in South Africa Management of Sickle Cell Disease - The United Republic of Tanzania Standards for Clinical Care of Adults with Sickle Cell Disease in the UK Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada Evidence-Based Management of Sickle Cell Disease ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children