treated with in guideline Behavioural Abnormality Depression http://www.who.int/topics/depression/en/ Depressive Symptoms A common mental disorder, characterized by sadness, hopelessness, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, feelings of tiredness, and poor concentration. Depression can be long-lasting or recurrent, substantially impairing an individual's ability to function at work or school or cope with daily life. SIO:000824 Low Mood Sufficient SCDO:0000360 Mental Health Psychotherapy Quality of Life Related SCD Symptoms and Complications National Guideline for the Control and Management of Sickle Cell Disease Management of Sickle Cell Disease - The United Republic of Tanzania A Parental Guide to Managing Sickle Cell Disease Standards for Clinical Care of Adults with Sickle Cell Disease in the UK Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit Evidence-Based Management of Sickle Cell Disease ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children