G6PD Exists in other ontologies but we have provided a description more relevant to its relationship with SCD. G6PD1 http://www.ncbi.nlm.nih.gov/gene/2539 G-6-PD Not relevant to context of sickle cell This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. Glucose-6-Phosphate Dehydrogenase Gene Glucose-6-Phosphate 1-Dehydrogenase Gene Non-Globin Gene