diagnosed using tool treated with has mode of inheritance has causal genotype has causal or contributing genetic variation has causal molecular phenotype Autosomal Recessive Gene Therapy Alpha Thalassemia Electrophoresis Hematopoietic Stem Cell Transplantation Hemoglobin Barts Hydrops Fetalis Hemoglobin Barts Hydrops Fetalis Syndrome Hb Barts Syndrome Suggest update to description in ORDO as we have done. http://www.orpha.net/ORDO/Orphanet_163596 Hemoglobin Bart's Hydrops Fetalis Hb Barts Homozygous Alpha 0-Thalassemia Haemoglobin Barts Hydrops Fetalis Alpha-Thalassemia Major Alpha-Thalassemia Hydrops Fetalis Suggest update to description The most severe form of alpha-thalassemia and is almost always lethal, and characterized by fetal onset of generalized edema, pleural and pericardial effusions, and severe hypochromic anemia. It is caused by the presence of Hemoglobin Barts, a hemoglobin with four gamma chains, which has an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues Orphanet:163596 Homozygous Deletion of HBA1 and HBA2 Gap PCR Cordocentesis Iron Chelation Therapy Absent Hemoglobin A