MYB http://www.ncbi.nlm.nih.gov/gene/4602 This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. MYB Gene Not relevant to context of sickle cell MYB Proto-Oncogene, Transcription Factor Exists in other ontologies but we have provided a description more relevant to its relationship with SCD. MYB-HSP1 Link to "Hereditary Persistence of fetal hemoglobin". Non-Globin Gene