diagnosed using tool treated with diagnosed using measurement Angiotensin-Converting Enzyme Inhibitors Nephrotic Range Proteinuria Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children, or urine protein to creatinine ratio >2000 mg/g [>200 mg/mmol] in children. Suggest update to description in HPO. HP:0012593 Is diagnosed by assessment of proteinuria (see Proteinuria) by 24hr urine collection or by urine protein-creatinine ratio on spot urine sample [KDIGO 2012]. Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children, or urine protein to creatinine ratio >2000 mg/g [>200 mg/mmol] in children. Glomerular diseases that lead to protein loss in the urine (See Nephrotic Syndrome). In sickle cell disease, seen primarily in adult population but may develop in childhood if secondary cause occurs. Nephrotic-Range Proteinuria Suggest update to description Proteinuria Urinary Albumin Test Urinary Creatinine Test Urinary Protein Measurement Urine Albumin Excretion Rate Urine Albumin-Creatinine Ratio Treatment of Precipitating Factors