in guideline Malaria Chemoprophylaxis Proguanil A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent. Cycloguanil stops the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite. Suggest update to description 1-(P-Chlorophenyl)-5-isopropylbiguanide N-(4-Chlorophenyl)-n'-(isopropyl)-imidodicarbonimidic diamide Chloroguanide MESH:D002727 Suggest update to description in MESH Chlorguanid Chlorguanide National Guideline for the Control and Management of Sickle Cell Disease Management of Sickle Cell Disease - The United Republic of Tanzania