diagnosed using tool has mode of inheritance has causal genotype has causal or contributing genetic variation has manifestation has causal molecular phenotype Complete Blood Count Splenomegaly Sickle Beta Thalassemia Hemoglobin S Hemoglobin Profile Assay Sickle Cell Disease-S/Lepore Boston Sickle Cell-Hemoglobin Lepore Boston Syndrome Sickle Cell-Hb Lepore Boston Syndrome SCD-S/Lepore Boston Hb Lepore Washington, also known as Hb Lepore Boston or Hb Lepore Washington-Boston; most common in Italians from Southern Italy. Request inclusion into relevant ontology Sickle Cell Disease-S/Lepore Sickle cell-Hb Lepore Boston syndrome is a type of sickle cell disease that differs from homozygous sickle cell disease where both parents carry sickle hemoglobin. In this variant one parent has the sickle cell hemoglobin the second parent has Hb Lepore Boston, the only one of the three Hb Lepore variants described in association with HbS. None SCDO (Jade Hotchkiss) HBB, GLU6VAL Hemoglobin Genotype S/Lepore Boston Hemoglobin Lepore Boston Crossover between delta (HBD) and beta globin (HBB) gene loci Autosomal Recessive Compound Heterozygous