in guideline Abnormality of the Kidney Sickle Cell Related Cancer Renal Medullary Carcinoma Renal medullary carcinoma is a rare, aggressive subtype of renal cell carcinoma characterized by a large, white or tan, firm, infiltrative tumor with microabscess-like foci centered in the renal medulla, typically presenting with hematuria, abdominal/flank pain, weight loss and fever. It is associated with sickle cell trait and disease and metastasis to the bones and lungs is common at time of diagnosis. Shetty A, Matrana MR. Renal medullary carcinoma: a case report and brief review of the literature. Ochsner J. 2014;14(2):270-5. Kidney Medullary Carcinoma SCDO:0001511 Sufficient Renal Medullary Cancer http://www.orpha.net/ORDO/Orphanet_319319 ORPHA:319319 RMC Management of Sickle Cell Disease - The United Republic of Tanzania Standards for Clinical Care of Adults with Sickle Cell Disease in the UK Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada Evidence-Based Management of Sickle Cell Disease