in guideline Ischemia Myocardial Ischemia EFO:1001375 http://www.ebi.ac.uk/efo/EFO_1001375 SCDO:0005464 Sufficient A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (coronary artery disease), to obstruction by a thrombus (coronary thrombosis), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction). Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada