diagnosed using tool has causal genotype has causal or contributing genetic variation has manifestation has causal molecular phenotype Splenomegaly Osteonecrosis Increased Hemoglobin F Genetic Testing Hemoglobin S Gap PCR HBG1 and/or HBG2 Mutations Sickle Cell Disease-S/HPFH Sickle Cell Disease-S/Persistence of Fetal Hemoglobin A group of disorders caused by large deletions of the beta-globin gene complex; typically 30% fetal haemoglobin. Hereditary Persistence of Fetal Hemoglobin-Sickle Cell Disease Syndrome Request inclusion into relevant ontology Sickle Cell Disease Syndrome-Hereditary Persistence of Fetal Hemoglobin Sickle Cell-Hereditary Persistence of Fetal Hemoglobin HPFH-Sickle Cell Disease Syndrome http://ac.els-cdn.com/S014067361061029X/1-s2.0-S014067361061029X-main.pdf?_tid=691c25c0-5826-11e7-b704-00000aacb35e&acdnat=1498230953_4d1264c47385275daf8fc2a1e1de62e3 None HBB, GLU6VAL HBB, 106-KB DEL Hemoglobin Genotype S/HPFH Compound Heterozygous Sickle Cell Disease Structural and Quantitative Hemoglobinopathy