causes or contributes to condition contributes to genotype causes or contributes to molecular phenotype Hemoglobin O-Arab Disease Hemoglobin O-Arab Trait Sickle Cell Disease-S/O-Arab Other HBB Variants Hemoglobin O-Arab HBB, GLU121LYS Request inclusion into relevant ontology Beta O-Arab Mutation Glu121Lys SCDO (Jade Hotchkiss) Contributing Beta S-Oman Mutation A mutation where the glutamic acid in position 121 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine. This mutation is found as a single alteration in Hemoglobin O-Arab and is one of the two contributing mutations to the production of Hemoglobin S-Oman. Negligable Hemoglobin Genotype S/O-Arab Hemoglobin S-Oman Hemoglobin Genotype A/S-Oman Sickle Cell Disease A/S-Oman Hemoglobin Genotype AO-Arab Hemoglobin Genotype O-Arab