causes or contributes to condition contributes to genotype causes or contributes to molecular phenotype Hemoglobin C Hemoglobin C Disease Hemoglobin C Trait Sickle Cell Disease-SC Other HBB Variants HBB, GLU6LYS SCDO (Jade Hotchkiss) Request inclusion into relevant ontology A mutation where the glutamic acid in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine. This mutation results in the production of Hemoglobin C and confers resistance to malaria. HbC Mutation Negligable Beta C mutation Hemoglobin Genotype SC Hemoglobin Genotype C/S Antilles Sickle Cell Disease C/S Antilles Hemoglobin Genotype AC Hemoglobin Genotype CC