causes or contributes to condition contributes to genotype causes or contributes to molecular phenotype Other HBB Variants HBB, LEU68PHE A mutation where the leusine residue in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by phenylalanine. This mutation on its own produces a stable hemoglobin that does not result in hemolysis (Hb Rockford), but when in combination with the Hb S mutation (HBB, GLU6VAL), the symptomatic Hb Jamaica Plain is produced. Negligable Perrault, J., Fairbanks, V. F., McCormick, D. J., Kubik, K., Madden, B. J., Holmes, M. W., Hoyer, J. D. Hemoglobin Rockford, beta68(E12)leu-to-phe: a new HB variant associated with mild anemia. (Abstract) Blood 90 (Suppl. 1): 30b, 1997. Request inclusion into relevant ontology Contributing Hb Jamaica Plain Mutation SCDO (Jade Hotchkiss) Hemoglobin Genotype A/Jamaica Plain Hemoglobin Jamaica Plain Sickle Cell Disease A/Jamaica Plain