causes condition has contributing genetic variation causes molecular phenotype Hemoglobin S Hemoglobin D-Punjab Sickle Cell Disease-S/D-Punjab HBB, GLU6VAL Hemoglobin Genotype S/D-Punjab Compound heterozygosity for the hemoglobin S (HBB Glu6Val) and hemoglobin D-Punjab (HBB Glu121Gln) variants. beta6Glu>Val/beta121Glu>Gln S/D-Punjab Genotype Hemoglobin Genotype S/D-Punjab Haemoglobin Genotype S/D-Punjab Torres LS, Okumura JV, Silva DG, Bonini-Domingos CR. Hemoglobin D-Punjab: origin, distribution and laboratory diagnosis. Rev Bras Hematol Hemoter. 2015;37(2): 120–126. pmid:25818823 None Hemoglobin Genotype SD HBB, GLU121GLN