causes condition has contributing genetic variation causes molecular phenotype Hemoglobin S HBB, GLU6VAL HBB, ASP73ASN SCD Genotype Hemoglobin Genotype S/C-Harlem PMID: 1148394 Haemoglobin Genotype S/C-Harlem Request inclusion into relevant ontology beta6Glu>Val/beta6Glu>Val, beta73Asp>Asn None SCDO Compound heterozygous inheritance of Hb S and Hb C-Harlem mutations. Hb S occurs from substitution of valine for glutamic acid in the beta-6 position (beta6Glu>Val). Hb C-Harlem involves two substitutions in each beta-chain: the first being identical to that found in Hb S, and the second being a substitution of aspartic acid at position 73 by asparagine (beta73Asp>Asn). S/C-Harlem Genotype Hemoglobin C-Harlem Sickle Cell Disease-S/C-Harlem