has causal or contributing genetic variation Abnormal Hemoglobin in SCD Abnormal Hemoglobin HBB, THR87ILE Hemoglobin Quebec Chori Suggest update to description Hb Quebec-Chori MESH:C070823 http://ac.els-cdn.com/S014067361061029X/1-s2.0-S014067361061029X-main.pdf?_tid=691c25c0-5826-11e7-b704-00000aacb35e&acdnat=1498230953_4d1264c47385275daf8fc2a1e1de62e3 An abnormal hemoglobin in which a threonine is replaced by an isoleucine residue at the eighty-seventh position of beta chains. It migrates like HbA but promotes sickling. Suggest update to description in MESH (the term in MESH doesn't currently have a description). Also request inclusion in the HPO, below "Abnormal Hemoglobin", for the sake of completion. Witkowska, H.E., Lubin, B.H., Beuzard, Y., Baruchel, S., Esseltine, D.W., Vichinsky, E.P. et al. Sickle cell disease in a patient with sickle cell trait and compound heterozygosity for hemoglobin S and hemoglobin Quebec-Chori. N Engl J Med. 1991; 325: 1150–1154