Abnormal Hemoglobin in SCD Abnormal Hemoglobin Hemoglobin Lepore Boston http://en.wikipedia.org/wiki/Hemoglobin_Lepore_syndrome#Homozygous_Hb_Lepore Suggest inclusion in the HPO, below "Abnormal Hemoglobin". Hb Lepore is produced at a reduced rate and this is why the disease is related to the Β-thalassemic syndromes. Quantity in heterozygotes 7-13%; found in combination with Hb S, Hb C, beta+-thal, and in the homozygous state. The most common Hb Lepore type; found mainly in Italian families; it has also been observed in families from Rumania, Yugoslavia, Turkey, Cyprus, Jamaica, Cuba, Greece, England, Australia, Mexico, etc Hemoglobin Lepore Boston-Washington The most common Hemoglobin Lepore type and the only type of the three known variants described in association with HbS. This abnormal hemoglobin consists of two normal alpha globin chains (HBA) and two deltabeta globin fusion chains which occur due to a crossover between the delta (HBD) and beta globin (HBB) gene loci during meiosis. http://globin.cse.psu.edu/html/huisman/variants/hybrid/Lepore-Boston-Washington.html Hb Lepore-B-W Hb Lepore-WB Hb Lepore-Boston-Washington Hb Lepore Boston-Washington Few but definitions not freely available Hemoglobin Lepore-Boston-Washington Hb Lepore-Washington-Boston