deprecated terms deprecated-Symptomatic Sickle Cell Trait true Often these individuals have co-inherited another hemoglobin mutation that decreases hemoglobin solubility (eg, HbS-Antilles; Hb-Quebec-Chori; HbS-Oman; Hb Jamaica Plain). Other rare causes of symptomatic sickle cell trait include: mosaicism for cells in which only the sickle mutation was expressed due to post-zygotic uniparental disomy, and when sickle cell trait coexists with pyruvate kinase deficiency, which lowers the hemoglobin oxygen affinity, resulting in hemoglobin S polymerization and sickling. Clinical Sickle Cell Disease in the Heterozygous State The condition in which an individual with sickle cell trait shows symptoms of sickle cell disease such as anemia or acute chest syndrome. Dominant Sickle Cell Disease Dominant Sickle Cell Disease