has mode of inheritance has causal genotype has causal or contributing genetic variation has manifestation has causal molecular phenotype Autosomal Dominant Hemolytic Anemia Hypoxia Structural Hemoglobinopathy HBB, GLU6VAL HBB, LEU68PHE Hemoglobin Genotype A/Jamaica Plain Hemoglobin Jamaica Plain Sickle Cell Disease A/Jamaica Plain Request inclusion into relevant ontology SCDO (Jade Hotchkiss) None Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation beta6 Glu > Val and a second beta68 Leu > Phe mutation.The other beta globin allele produces normal beta globin chains. Dominant Sickle Cell Disease